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MK-677 is used by athletes to gain a competitive edge in sports. MK-677 binds to the ghrelin receptor, mimicking the effects of ghrelin. These effects included increased appetite, muscle mass, bone mineral density, angiogenesis, VEGF expression, protection of the heart, and modulation of glucose and energy homeostasis.
1. Reversal of Nitrogen Wasting
MK-677 can stop the nitrogen wasting effect of a caloric deficit on the body. This means that as you limit your calories and exercise more to lose weight, your body won't resort to breaking down your muscles for energy.
In study participants, MK-677 helped them to maintain muscle mass and instead use their fat stores as energy.
2. Less Fat Stored
Supplementing with MK-677 can influence where your body stores the calories you eat. In most people, when we eat more calories than we burn in a day some of those calories will be stored as fat.
MK-677 changes that, and instead your body deposits those calories into the muscles, resulting in muscle growth.
3. Increased Bone Mineral Density
Older adults who were given MK-677 as part of a clinical study saw increases in bone density and strength.
This means that the supplement can decrease the risk of developing degenerative bone diseases like osteoporosis and help to maintain bone health in older adults.
I weigh about 165 pounds, and take between 12-15 mg per day (15mg on training days). When I first started, I was taking MK-677 every weekday, then stopping on weekends (with a M/W/F training routine).
Then I switched to training 4-5 days per week, and started taking it every day. I did notice any side effects from taking it daily. However, now I take it 6 days per week (with Sunday off), 15 mg on training days and 10-12 mg on rest days.
As a smaller guy, the 15mg dose works fine for me. Some close friends of mine take around 25-30 mg of MK-677 on a 5/2 schedule, but have much higher water retention. In the end, I prefer a more athletic look. If you're just trying to bulk, then 30 mg or so will certainly help.