Anastrozoles Arimidex Anabolic Androgenic Steroid Powder Arimidex Pharmaceutical
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Anastrozole Arimidex Estrogen Suppression Breast Cancer Treatment
Also known as: Arimidex; 120511-73-1; anastrazole; Anastrozol; ZD-1033; ICI D1033; ZD1033; Anastrole; Asiolex
Anastrozole Arimidex CAS: 120511-73-1
Anastrozole Arimidex Assay: 98.0%--102.0%. USP32
Anastrozole Arimidex Packing: Discreet package according to the request.
Anastrozole Arimidex Delivery: Courier.
Anastrozole Arimidex MF: C17H19N5
Anastrozole Arimidex MW: 293.37
Anastrozole Arimidex Character: White crystalline powder.
Anastrozole Arimidex MP 81-82°C.
Anastrozole Arimidex Usage: An aromatase inhibitor. Used as an antineoplastic raw materials.
Arimidex (Anastrozoles Arimidex) is a non-steroidal drug which is used to treat breast cancer. It has been thoroughly studied in women with breast cancer between the 5th-8th decades of life. There are some breast cancers which are dependent on estrogen for their growth. Arimidex acts by suppressing the levels of estrogen in the body and thus reduces the growth of breast cancer. The drug is first line treatment in post menopausal women with early breast cancer or in those with advanced breast cancer despite taking tamoxifen. Arimidex is often combined with other drugs to treat breast cancer in post menopausal women. The drug has been used to treat early or advanced breast cancer in women all cultures and races.
Arimidex is not a large molecule but still it is not very soluble in water. Because of its organic structure, it is more soluble in alcohols like methanol, acetone, ethanol and acetonitrile. When taken orally, Arimidex enters the liver where more than 90% is broken down into inactive metabolites. In individuals who have mild liver disease, cirrhosis or have alcoholic liver problems, the drug is safe. However, in individuals with severe liver disease, the drug does have the potential to cause side effects.
Because Arimidex is not excreted in the urine, people with kidney impairment can take the drug without any dosage changes. Further, the drug dosage does not have to be altered in the elderly individuals either.
Arimidex in the US is administered by physicians who specialize in the treatment of cancer. Arimidex is sold as a pill containing 1 mg of anastrozole. The formulation of the pill also contains other inactive chemicals like lactose, magnesium sterate, polyethylene glycol, sodium starch glycolate and titanium dioxide. These ingredients make the active anastrozole more soluble in water, and make it easier to prepare as a pill.
Arimidex is taken orally everyday as a 1-mg tablet. All the patients with advanced breast cancer who have been prescribed the drug take it until a response in the tumor is seen. For those patients who take Arimidex as part of adjuvant (a substance that helps and enhances the pharmacological effect of a drug) therapy, the exact duration of the treatment remains unknown but most experts recommend that women take it for 5 years.
Mode of Action
Some breast cancers have estrogen receptors and these breast caners are stimulated to grow by the estrogen in the body. In post menopausal women, the primary source of estrogen is from the conversion of androstenendione (made in the adrenal gland) in the fatty tissues to estrone. In the fatty tissues there is an enzyme known as Aromatase which can covert this hormone into estradiol, the female sex hormone. Studies have also shown that some breast cancers also contain this enzyme, aromatase. In the days gone by, one of the ways to decrease the levels of estrogen in the body was by removing the ovaries. Today, however, anti-estrogen drugs are preferred to surgery. One of the first anti-estrogen drug used to treat breast cancer was tamoxifen. Numerous trials have shown that anti-estrogen drugs can significantly decrease breast cancer size.
Indications for Arimidex
Arimidex has three general indications:
- Arimidex is recommended for the treatment of post menopausal women who have early breast cancer which is hormone sensitive (estrogen positive).
- It is also indicated as the first line treatment of post menopausal females who have spread of breast cancer either locally or systemically, irrespective of the hormonal status of the breast cancer.
- It is also indicated in the treatment of advanced breast cancer in post menopausal women who have further growth of breast cancer following treatment with tamoxifen. Women who do not have estrogen receptor positive breast cancer and those who do not show any response to tamoxifen generally do not respond to Arimidex.
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